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Weight Loss History

The first described attempt at producing weight loss is those of Soranus of Ephesus, a Greek physician, in the second century AD. He prescribes elixirs of laxatives and purgatives, as well as heat, massage, and exercise. This remains the mainstay of treatment for well over a thousand years. It was not until the 1920s and 1930s that new treatment begins to appear. Based on its efficiency for hypothyroidism, thyroid hormone became a popular treatment for obesity in otherwise healthy people.

It had a modest result but produced the symptoms of hyperthyroidism as a side effect, such as palpitations and difficulty sleeping. Dinitrophenol (DNP) was introduced in 1933; this worked by separation the biological process of oxidative phosphorylation in mitochondria, causing them to produce heat instead of ATP. The most important side effect was a sensation of warmth, frequently with sweating. Today weight loss is possible without side effects or without unpleasant sensations, while losing pounds safely.


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